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Y Kawaguchi Selected Research

Insulin (Novolin)

5/2006Expression of the gene for a membrane-bound fatty acid receptor in the pancreas and islet cell tumours in humans: evidence for GPR40 expression in pancreatic beta cells and implications for insulin secretion.
11/2001Insulin secretion to glucose as well as nonglucose stimuli is impaired in spontaneously diabetic Nagoya-Shibata-Yasuda mice.
4/2001The Pro12 -->Ala substitution in PPAR-gamma is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals with type 2 diabetes.
7/2000Age-dependent changes in phenotypes and candidate gene analysis in a polygenic animal model of Type II diabetes mellitus; NSY mouse.

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Y Kawaguchi Research Topics

Disease

11Neoplasms (Cancer)
08/2016 - 03/2000
5Systemic Scleroderma (Systemic Sclerosis)
06/2011 - 12/2003
4Pancreatic Neoplasms (Pancreatic Cancer)
11/2011 - 01/2000
4Esophageal Squamous Cell Carcinoma
07/2010 - 08/2007
4Type 2 Diabetes Mellitus (MODY)
11/2001 - 07/2000
3Systemic Lupus Erythematosus (Libman-Sacks Disease)
07/2019 - 11/2001
3Adult-Onset Still's Disease
08/2006 - 07/2001
3Chronic Kidney Failure (Chronic Renal Failure)
02/2002 - 07/2000
3Rheumatoid Arthritis
02/2002 - 08/2001
2Inflammation (Inflammations)
12/2012 - 06/2000
2Thrombosis (Thrombus)
01/2012 - 11/2009
2Necrosis
06/2011 - 06/2010
2Interstitial Lung Diseases (Interstitial Lung Disease)
12/2009 - 03/2008
2Dental Plaque
06/2009 - 09/2007
2Dental Caries (Decay, Dental)
06/2009 - 06/2000
2Insulin Resistance
05/2006 - 07/2000
2Intervertebral Disc Displacement (Herniated Disc)
11/2003 - 09/2000
2Secondary Hyperparathyroidism
02/2002 - 03/2000
2Osteoid Osteoma
12/2001 - 10/2000
2Crohn Disease (Crohn's Disease)
05/2001 - 05/2001
2Type 1 Diabetes Mellitus (Autoimmune Diabetes)
05/2001 - 06/2000
2Peritonitis
07/2000 - 05/2000
2Carcinoma (Carcinomatosis)
04/2000 - 01/2000
1Neoplasm Metastasis (Metastasis)
01/2021
1Lymphatic Metastasis
01/2021
1Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune)
07/2019
1Autoimmune Hemolytic Anemia (Cold Agglutinin Disease)
07/2019
1Macrophage Activation Syndrome
07/2019
1Lupus Nephritis
07/2019
1Brain Injuries (Brain Injury)
12/2018
1Liver Diseases (Liver Disease)
12/2016
1Non-alcoholic Fatty Liver Disease
12/2016
1Metabolic Syndrome (Dysmetabolic Syndrome X)
12/2016
1Colorectal Neoplasms (Colorectal Cancer)
08/2016
1Chronic Hepatitis C
04/2013
1Dementia (Dementias)
10/2012
1Multiple System Atrophy
10/2012
1Parkinson Disease (Parkinson's Disease)
10/2012
1Colonic Neoplasms (Colon Cancer)
01/2012
1Hepatocellular Carcinoma (Hepatoma)
01/2012
1Hepatic Insufficiency
11/2011
1Disease Progression
06/2011
1Ischemia
06/2011
1Squamous Cell Carcinoma (Epidermoid Carcinoma)
08/2010
1Exanthema (Rash)
01/2010

Drug/Important Bio-Agent (IBA)

9Proteins (Proteins, Gene)FDA Link
10/2012 - 04/2000
4Insulin (Novolin)FDA Link
05/2006 - 07/2000
3Glucose (Dextrose)FDA LinkGeneric
05/2006 - 07/2000
3Indicators and Reagents (Reagents)IBA
12/2003 - 05/2000
3Interleukin-18 (Interleukin 18)IBA
11/2002 - 07/2001
3Prednisolone (Predate)FDA LinkGeneric
11/2001 - 06/2001
3CytokinesIBA
01/2001 - 05/2000
2Biomarkers (Surrogate Marker)IBA
07/2019 - 12/2016
2Peptides (Polypeptides)IBA
12/2012 - 05/2000
2GemcitabineFDA Link
06/2011 - 01/2010
2Monoclonal AntibodiesIBA
08/2010 - 11/2008
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
06/2010 - 08/2001
2Trastuzumab (Herceptin)FDA Link
02/2010 - 08/2007
2Cetuximab (Erbitux)FDA Link
02/2010 - 08/2007
2AutoantibodiesIBA
05/2009 - 05/2001
2Arginine (L-Arginine)FDA Link
12/2003 - 11/2001
2Nitric Oxide (Nitrogen Monoxide)FDA Link
12/2003 - 07/2000
2Codon (Codons)IBA
02/2002 - 01/2000
2Cyclooxygenase 2 (Cyclooxygenase-2)IBA
12/2001 - 10/2000
2CollagenIBA
10/2001 - 05/2000
2Hematoxylin (Haematoxylon)IBA
10/2001 - 09/2000
2Eosine Yellowish-(YS) (Eosin)IBA
10/2001 - 09/2000
2AntigensIBA
06/2001 - 01/2000
2LigandsIBA
05/2001 - 06/2000
2Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA
05/2001 - 05/2000
2Fluorouracil (Carac)FDA LinkGeneric
10/2000 - 06/2000
2Interleukin-6 (Interleukin 6)IBA
06/2000 - 05/2000
1ImmunosorbentsIBA
07/2019
1Inosine Triphosphate (ITP)IBA
07/2019
1EnzymesIBA
07/2019
1Small Interfering RNA (siRNA)IBA
08/2016
1CalcineurinIBA
08/2016
1Adrenal Cortex Hormones (Corticosteroids)IBA
04/2016
1InterleukinsIBA
04/2013
1Inosine TriphosphataseIBA
04/2013
1LipopolysaccharidesIBA
12/2012
1SynucleinsIBA
10/2012
1Ethiodized Oil (Ethiodol)FDA Link
01/2012
1ChemokinesIBA
07/2010
1InterferonsIBA
06/2010
1PerforinIBA
06/2010
1interleukin-21 (interleukin 21)IBA
02/2010
1Dexamethasone (Maxidex)FDA LinkGeneric
01/2010
1anti-scl-70 autoantibodiesIBA
12/2009

Therapy/Procedure

11Therapeutics
12/2018 - 03/2000
3Drug Therapy (Chemotherapy)
01/2021 - 10/2001
3Immunotherapy
08/2010 - 10/2001
3Renal Dialysis (Hemodialysis)
02/2002 - 06/2000
3Enteral Nutrition (Feeding, Tube)
05/2001 - 05/2001
2Ligation
11/2011 - 05/2001
2Peritoneal Dialysis
02/2008 - 07/2000
2Continuous Ambulatory Peritoneal Dialysis (CAPD)
02/2008 - 05/2000
1Colectomy
01/2012
1Pancreatectomy
11/2011
1Premedication
01/2010